Identification of differentially expressed genes in human lung
Identification of differentially expressed genes in human lung adenocarcinoma: ERGIC3 as a novel lung cancer-related gene Mingsong Wu Department of Cell Biology and Genetics Zunyi Medical University China Las Vegas 2014.10
Part I 1 Background 1 epidemiology of lung cancer ortality in lung cancer in selected count 1950 2006 Jemal et al.Cancer Epidemiology, Biomarkers & Prevention. (2010)
Subtype of lung cancer lung cancer small-cell small-cell lung lung carcinoma carcinoma
Higher quality Higher efficiency Part II 1 Background (Endoplasmic reticulum-Golgi intermediate compartment 3 ERGIC3) Cycles between the endoplasmic reticulum and Golgi II type transmembrane protein, 383 aa, 43.2 kDa Herzog et al. 2006
Mutation: COPII 25 Accumulation of protein and lipid in ER Inhibits ER stress-induced cell death FUNCTION? TUMOR MARKER 2 RESULTS Expression of ERGIC3(2^CT)
2.1 Expression of ERGIC3 in NSCLC 2.1.1 mRNA of ERGIC3 0.025 P=0.0001
0.020 0.015 0.010 0.005 0.000 Tu m
or n m n o ig al
nt a n 2.1.2 Protein of ERGIC3 2.1.3 Protein of ERGIC3 Evaluation of immunohistochemical positivity in lung cancer tissues
Tumour and clinicopathological features Gender Male Female Histological type* AC SCC
TNM stage I + II III + IV Differentiation* Poor Well or Moderate Smoking No Yes
rate:88.57% Score: , no staining;AC>SCC +, <30%; ++, 3160%; +++, >60% positive cells 2.1.4 Location of ERGIC3 2.1.4 Location of ERGIC3 2.2 Functions of ERGIC3 in lung
cancer 2.2.1 ERGIC3 promotes cellular growth 2.2.2 ERGIC3 promotes cellular migration 2.2.3 Stable overexpression of ERGIC3 promotes
cellular migration 3 Summ ary
Library of differentially expressed genes in lung cancer. Potential targets for diagnostic & therapeutic usage. Two lung cancer associated genes. ERGIC3 may be a new biomarker for lung cancer. ERGIC3 may be a novel candidate oncogen for lung cancer.
Karina. Mandre. Page . ... LNH 87 PERIPHERAL T CELL LYMPHOMA Cox's analysis survival OVERALL SURVIVAL OF THE 156 PATIENTS WITH ANGIOIMMUNOBLASTIC T-CELL LYMPHOMAS: LNH 87-LNH93 Diapositive 7 Diapositive 8 Event Free Survival Diapositive 10 WHERE IS THE PROBLEM ?...
Chiffres 1 femme sur 5 au Canada est handicapée 55% des personnes handicapées sont des femmes 60% des femmes en situation de handicap vivront de la violence au cours de leur vie adulte. Violence conjugale: femmes en situation de handicap...
Arial MS Pゴシック Calibri Office Theme Ramayana in Performance Sept. 15, 2011 Slide 2 Ramayana Art Ramayana Art from the Metropolitan Museum, NYC Story Cloths Ramayana Performances - India Ramayana Performances Southeast Asia Ramayana Performance Indonesia (Java/Bali) Ramayana Puppetry -...
We are a leader in healthcare with a comprehensive portfolio of innovative solutions which includes coverage for Medicaid, Medicare and the Health Insurance Marketplace. We also contract with other healthcare and commercial organizations to provide specialty services to help people...
Ready to download the document? Go ahead and hit continue!