Chapter ___: Chromosome

Chapter ___: Chromosome

Chapter 8: Chromosome 8 DNA Sequence Chromosome Name of Gene 8 TG 267,987 bp Name of Protein thyroglob ulin transcription . mRNA Amino acid sequence

2768 aa translation What does this protein make up or do? Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine Condition/Disease thyroid Description of Thyroid Dyshormonogenesis Symptoms and characteristics Genetic Defect that causes Thyroid swelling

This is due to the Thyroid gland not producing enough of important hormones Thyroid Dyshormonogenesis is cured by taking a pill from your doctor to cut down the swelling. Swollen Thyroid Thyroid Dyshormonogenisis Dyshormonogenesis is caused by hereditary defects in the steps of thyroid hormone synthesis and secretion. It is transmitted in a recessive manner but at least one condition has autosomal dominant inheritance.

Iodine is added to all drinking water, it is a hormone that reduces the chance of thyroid dyshormonogenisis. infants start on treatment early when detected at birth Thyroid Dyshormnogenisis affects IQ and the persons ability to learn, however the sooner treated the better. References Oprahnet. Dr Stephen LAFRANCHI. 2010. [cited 2015 March 2]. Available at URL: http://www.orpha.net/consor4.01/www/cgi-bin/O C_Exp.php?lng=EN&Expert=95716 Genetics Home Reference. 2006. [cited 2015 March 2]. Available at URL: http://ghr.nlm.nih.gov/gene/TG http://www.ncbi.nlm.nih.gov/projects/genome/gui de/human/index.shtml

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