Auditory System - zhanglab.wdfiles.com

Auditory System - zhanglab.wdfiles.com

Auditory System Objectives Review the anatomy of ears Correctly order the steps of inner ear response Explain the brain mechanism for sound localization Draw the central auditory pathway Understand the common audiometric/special hearing tests

Process of hearing 1. Sound waves strike the tympanic membrane 2. Then the sound waves are transmitted through middle ear and cochlear fluid in inner ear 3. The cochlear hair cells are activated and send the signal through CN VIII to brainstem 4. The signals go through several synapses before reaching thalamus, and then finally A1 cortex Ear Anatomy

The hair cells Outer hair cells 3 rows at base 5 rows at apex The number is around 12,000 Connected to the projections from the descending auditory

pathways Inner hair cells 1 row The number is around 3,500 Innervated by the cochlear nerve endings Form most of the afferent fibers

The place principle base apex The pitch of a sound determines which cells are activated

Video How sound is converted into electric signal https://www.youtube.com/watch?v=1JE8WduJKV 4 From 1:29, or 3:31 Useful website Journal into the world of hearing http://www.cochlea.eu/en/ear

Auditory Pathways to Auditory cortex to medial geniculate body to Inferior colliculus through Lateral lemniscus Dorsal cochlear nucleus Thalamus: the relay center for most of the sensory inputs Receive tonotopic input from the

ipsilateral inferior colliculus Send information to the ipsilateral temporal lobe (the gyri of Heschl in the superior temporal lobe) Hearing impairment Conductive hearing loss Sensorineural hearing loss Mixed hearing loss

Central auditory impairment Sensorineural hearing loss Damage to the cochlear hair cell or auditory nerve Difficulty in understanding speech, particularly in noise Causes: Prolonged exposure to noise Tumor Diseases Menieres disease

Presbycusis Central auditory impairment Lower brainstem Superior olivary nucleus: minimal effect on hearing sensitivity, but troubles in localizing sound source and processing temporal information

Lateral lemniscus: no severe hearing impairment, but subtle symptoms like impaired processing of speech in noise Upper brainstem Inferior colliculus: impaired auditory reflex and sound integration

Medial geniculate body: difficulties in sound integration and attending to sound Cortical involvement Near-normal-hearing threshold, but impaired speech processing Evaluations

of Hearing impairment Tuning fork tests Pure tone audiometry Tympanometry Otoacoustic emission Auditory brainstem response audiometry Pure tone audiometry Establish the threshold of hearing

across frequency Most reliable test for evaluating hearing sensitivity Tympanometry Measure compliance of tympanic membrane and middle-ear pressure Impaired tympanic membrane compliance indicates middle ear pathology

Otoacoustic emmision Measure pressure wave elicited by the movement of the outer hair cell in cochlea Newborn hearing screening program Auditory brainstem response audiometry Measure the neuronal activity from

the brainstem auditory pathway Each peak is thought to be generated at a different anatomic point in the auditory pathway ex l p m s

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Auditory brainstem response audiometry Vestibular System Objectives The anatomy of vestibular system Vestibular pathway Vestibular projections and some of their functions Examples of vestibular dysfunction

Where Anatomy of vestibular system Semicircular ducts Vestibule Utricle Saccule

Semicircular ducts/canals Endolymph filled Right angles to one another, detect acceleration in various planes Anterior Posterior Lateral

Video https://www.youtube.com/watch?v=YMIMvBa8X Gs How the three semicircular ducts detect the head motion Start from 0:20 Projections to Cerebellum Most of the projections from vestibular nuclei

Form bidirectional projections Constant and updated vestibular feedback Monitoring body and head position Regulate muscular adjustment Maintenance of body equilibrium

Projections to Spinal cord A descending projection Enter the ventral column of the spinal cord Terminate at different spinal levels Maintain the muscle tone to counteract the gravity Projections to some CNs Through medial longitudinal fasiculus to

Oculomotor CN III Trochlear CN IV Abducens CN VI Spinal accessory nerve CN XI

Coordinate eye and head movements Some clinical correlates Motion sickness Subjective sensation of body rotation

Associate with dizziness, nausea, and vomiting Repeated up and down movements Conflict information from inner ears and eyes Vertigo Subjective: sensation of spinning through the space Objective: sensation of environmental spinning around oneself

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